The research group, headed by Dr. Michael Schmueck-Henneresse, is interested in how T cells protect us from viral infections and chronic diseases caused by pathogens, tumors or autoimmunity. The group focuses on how T cells coordinate an effective immune memory against virus-infected or malignant cells and how this can be specifically attenuated in autoimmune diseases or after organ transplantation. To this end, we are developing technologies that can detect, characterize and genetically reprogram T cell specificity, as well as strategies to optimize the quality of T cells for therapeutic purposes. Our goal is to develop diagnostic tools to predict the immune response, as well as to provide new treatment options by developing appropriate T cell products.
- The isolation, generation and functional evaluation of CONAN CAR T-cell products: Conducting experimental work, establishing gene editing procedures, testing the functional potency of the cells, further developing hypotheses.
- The functional testing of CONAN T cells and the establishment of a solid-tumor organ-on-a-chip model.
- Test the infiltration capacity and efficacy of CONAN CAR T cells, focusing on clinically relevant human organ-on-a-chip technology to test the infiltration capacity and efficacy of CONAN CAR T cells.
- Supervision of practical work of PhD students.
- Researcher in immunology, cancer biology, or another field relevant to tumor biology
- completed university studies and experimental doctorate in medicine or a life science
- practical experience in performing standard methods of cell culture and molecular biology
- project management and coordination skills
- excellent command of written and spoken English
- preferably experience with all methods necessary for the application of genetic engineering (e.g CRISPR-Cas9-based genetic engineering) and molecular biology (PCR, Western immunoblotting, cloning, etc.).
- an interesting application-oriented and clinically relevant field of research
- a broad spectrum of established immunological and molecular biological methods
- Creative development opportunities in the establishment of new methods as well as the implementation of the project
- access to highly innovative technologies
- Interdisciplinary research approaches and embedding in a diverse scientific network
- Freedom to work independently in an international team
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