Over 1.4 million children with heart disease are born every year, many
of them with a defect cardiac valve. Various valve prostheses are available for
adult patients, but none has been specifically developed for children. If a
replacement valve between right ventricle and pulmonary artery is necessary,
the majority of young patients receive an implant derived from a bovine jugular
vein. Older children may receive small
valves from bovine pericardium or porcine material. All valves originating from
non-human material are being recognized and attacked by the young patients’
immune system – leading to their gradual deterioration. Frequent follow-up
surgery is necessary, which impacts implant function and quality of life.
The state-of-the-art for children with heart disease is not good enough!
The RESTORE initiative works towards the development and implementation
of Advanced Therapies in clinical routine, e.g. a heart valve replacement for
children that is well tolerated and requires fewer follow-up procedures. Pioneering
spirit and new technologies are behind this paradigm shift in clinical care: growing
valve implants from patient tissue, modification of patient tissue, 3D bioprinting
and sustainable biological cross-linking methods. The result will be a
tailored, individually adapted heart valve from autologous tissue that is being
accepted by the child`s immune system. Advanced Therapies hold the potential
for an increased quality of life.
That is why RESTORE works towards the development and implementation of
innovative and safe Advanced Therapies in clinical care.
Please read more about the biological heart valve implants at