Autoimmunity and Autoinflammation
first Day of Immunology (DoI), an initiative created by the European Federation
of Immunological Societies (EFIS), was celebrated on 29th April 2005,
gathering together immunologists across Europe to bring immunology to the
attention of the public. Due to its great success, DoI has been celebrated
annually on the 29th April worldwide since 2007. The purpose of DoI
is to strengthen public awareness of immunology and encourage immunologists to
explore the art of public relations in order to convey their knowledge to an
audience outside of the scientific community.
year DoI is dedicated to increasing global awareness and promoting the benefits
of immunology research, particularly with respect to autoimmunity and
autoinflammation. Understanding the immune system is key to the function of
many medications and preventative treatment regimens such as vaccines. The
importance of understanding how the immune system functions has been thrown
into stark relief with the current COVID-19 situation, in which researchers
across the globe are striving to understand how the SARS-CoV-2 virus affects the
human body, how the immune system reacts to the virus and how this can be
exploited to treat patients suffering with COVID-19.
brings together researchers, clinicians and developers across multiple
disciplines, including immunology, to bring novel Advanced Therapy Medicinal
Products (ATMPs) to the European community and beyond. Many of the ATMPs under
development utilise our understanding of the immune response to certain diseases
and conditions to develop novel treatment options. The goal of RESTORE is to
support the development of ATMPs that do not just alleviate symptoms but rather
act to cure chronic diseases.
such example of harnessing the immune system to reshape undesired immune
responses or to restore immunocompetence is the use of regulatory T cells
(Tregs). This unique T cell lineage is essential for maintaining immune
tolerance to self as well as innocuous environmental antigens and intratissue
immune homeostasis. A reduced number or function of these cells can result in unwanted
inflammation/immunity associated with autoimmunity, autoinflammation, and
disturbed regeneration from trauma and ischemia/reperfusion. As such,
harnessing this aspect of the immune system could be used to treat a variety of
autoimmune and auto-inflammatory conditions. E.g. the use of Tregs to “cure”
rejection of the kidney after transplantation.
learn more about the immune system this 29th April, explore the
exciting resources contained within the links below!